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Protein Kinase D, The Journal of Experimental Medicine

Jun 19, 2000PKD exhibited negligible basal activity in nonstimulated JH6.2 cells, and stimulation of the TCR complex led to a rapid increase in PKD activity, similar to that observed in peripheral blood–derived T cells. View larger version: In this window In a new window Download as PowerPoint Slide Figure 2 TCR stimulation induces PKD catalytic activity.

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Structural and Thermodynamic Basis of the Enhanced

For a better understanding of protein–inhibitor interactions, we report structural, thermodynamic, and biological analyses of the interactions between S-trityl-l-cysteine (STLC) derivatives and the motor domain of kinesin spindle protein Eg5. Binding of STLC-type inhibitors to Eg5 was enthalpically driven and entropically unfavorable. The introduction of a para-methoxy substituent in one

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Hematopoietic progenitor kinase 1 is a critical component

Sep 29, 2009Lung cancer is the leading cause of cancer-related mortality in the world, resulting in over a million deaths each year. Non-small cell lung cancers (NSCLCs) are characterized by a poor immunogenic response, which may be the result of immunosuppressive factors such as prostaglandin E2 (PGE2) present in the tumor environment. The effect of PGE2 in the suppression of anti-tumor

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The biology and biochemistry of diacylglycerol signalling

Protein families with C1 domains. Diagram of protein families with C1 domains that are known to bind diacylglycerol (DAG). Other domains are also shown, including calcium and phospholipid‐binding C2 domains in protein kinase Cs (PKCs) and Munc13, pleckstrin homology (PH) domains in protein kinase D (PKD), EF hands and ankyrin repeats in DAG kinases (DGKs), serine/threonine kinase domains in

The single

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Phenolic

Sep 17, 2012Advanced stages of leprosy show T cell unresponsiveness and lipids of mycobacterial origin are speculated to modulate immune responses in these patients. Present study elucidates the role of phenolicglycolipid (PGL-1) and Mannose-capped lipoarabinomannan (Man-LAM) on TCR- and TCR

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Annexure III:TVM KLM PTA ALP KTM IDK EKM TCR PKD MLP WND KKD KNR KSD. 03.05.2013: Ratio promotion of Junior Health Inspector Gr II – details called for: 03.05.2013: Whereabouts of Staff Nurse – called for: 30.04.2013: IT Department – PG Diploma in e-Governance – applications invited: 29.04.2013

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Gβγ

Protein kinase D (PKD) constitutes a novel family of serine/threonine protein kinases implicated in fundamental biological activities including cell proliferation, survival, migration, and immune responses. Activation of PKD in these cellular activities has been linked to many extracellular signals acting through antigen receptor engagement, receptor tyrosine kinases, as well as G protein

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